Exercise Boosts Fat and Protein Metabolism in Diabetic Patients

-

Exercise Boosts Fat and Protein Metabolism in Diabetic Patients

In the body, glucose, fat, and protein serve as major energy sources, and they can be converted or interchanged as needed. However, in diabetes, where insulin function is impaired and mitochondrial function in skeletal muscle cells is compromised, disorders in lipid and protein metabolism accompany glucose metabolism issues.

Lipid metabolism disorders in insulin resistance often stem from various metabolic dysfunctions. When triglyceride metabolism defects occur in adipose tissue, it leads to an accumulation of free fatty acids in the liver, triggering the overproduction of large, very low-density lipoprotein particles and causing high blood pressure and hypertriglyceridemia.

Insulin plays a crucial role in stimulating cell protein synthesis and inhibiting protein breakdown. In diabetes, insufficient insulin or reduced effectiveness results in weakened protein synthesis, increased protein breakdown, and a negative nitrogen balance. This imbalance primarily affects skeletal muscle and liver, leading to muscle atrophy and decreased plasma protein synthesis.

Exercise not only improves glucose metabolism in diabetes but also addresses lipid and protein metabolism issues. During exercise, skeletal muscles utilize oxidized free fatty acids for energy at rest and rely on a combination of glucose, muscle glycogen, and free fatty acids during activity. As exercise progresses, muscles tap into glucose from liver glycogen breakdown and gluconeogenesis. Enhanced fat mobilization from adipose tissue during exercise increases blood free fatty acid levels, which are then taken up and oxidatively metabolized by muscles and the liver. Triglycerides stored in skeletal muscles also serve as important energy sources during exercise.

Studies indicate that moderate-intensity exercise can significantly increase fat oxidation, reducing lipid accumulation in adipose and muscle cells and ultimately enhancing skeletal muscle insulin sensitivity. Exercise can reverse the negative nitrogen balance in diabetes, increase skeletal muscle mass, and improve insulin resistance associated with aging. The underlying mechanisms likely involve improved endothelial function, insulin-mediated vasodilation, and nutrient delivery to muscles.

In summary, exercise plays a vital role in improving not only glucose metabolism but also lipid and protein metabolism in diabetes, offering holistic benefits for overall health and insulin sensitivity.

References

1.Chinese Guidelines of Exercise Therapy in Diabetes Mellitus

Comments

Post a Comment

Popular posts from this blog

Swimming Controlling Blood Pressure and Blood Sugar Levels in Men

-
Image
Swimming Controlling Blood Pressure and Blood Sugar Levels in Men Introduction: Hypertension (high blood pressure) and hyperglycemia (high blood sugar levels) are two prevalent health concerns among men worldwide. While medication and dietary changes are often recommended for managing these conditions, incorporating regular swimming into one's lifestyle can provide additional therapeutic benefits. In this article, we explore how swimming serves as an effective strategy for controlling blood pressure and blood sugar levels in men. Cardiovascular Health Benefits: Swimming is a cardiovascular exercise that engages large muscle groups and elevates the heart rate. This sustained aerobic activity strengthens the heart muscle and improves circulation, leading to better blood pressure regulation. Regular swimming sessions can help men achieve and maintain healthy blood pressure levels, reducing the risk of hypertension and related complications such as heart disease and stroke. Stress Redu
Read more

The Role of Exercise in Preventing Type 2 Diabetes

-
Image
 The Role of Exercise in Preventing Type 2 Diabetes Type 2 diabetes is primarily linked to a sedentary lifestyle and obesity, with over 80% of cases attributed to these factors. Engaging in regular exercise can substantially reduce the risk of developing diabetes, making physical inactivity a significant contributor to its onset. Various forms of exercise, from walking to vigorous activities, have been shown to lower the risk of diabetes. The intensity of the exercise correlates with the reduction in relative risk, indicating that more vigorous activities lead to greater risk reduction. Even simple activities like brisk walking or cycling once a week can improve fasting blood sugar control and lower the incidence of diabetes. Consistent daily physical activity can further decrease the relative risk by 15% to 60%. internationally studies affirm that both leisure-time sports and daily exercise significantly mitigate the risk of diabetes. Obesity, a key risk factor for diabetes, is closel
Read more

The Potential of Swimming in Alzheimer's Prevention

-
Image
The Potential of Swimming in Alzheimer's Prevention In a world where Alzheimer's Disease (AD) is becoming an increasingly prevalent concern, the search for effective prevention and treatment methods is more crucial than ever. Recent research suggests that swimming, as an aerobic exercise, could hold significant promise in this regard. The article "Swim Everyday to Keep Dementia Away", published online by PMC on March 1, 2005,  Providing Theoretical Basis， sheds light on the potential benefits of swimming in combating AD. Promoting Brain Health: Swimming has been shown to enhance blood flow and oxygen supply to the brain, thereby improving brain health, particularly in cognitive functions. Studies indicate that exercise-induced irisin can increase synaptic connections in the AD brain, enhancing memory. Reducing Disease Risk: Regular swimming may contribute to lowering the risk of developing Alzheimer's Disease. By adhering to a healthy lifestyle, including regular
Read more